Sunday, February 22, 2015

Scientists that died in the pursuit of great discoveries

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Paving the way for great discoveries and inventions is one of the biggest achievements for a scientist. The endeavor, however, comes with the risk that the journey into the unknown could be a deadly one.

KNow Science Blog - February 22nd 2015                                                                                                                                                     By Simona Giunta    


Here are 12 examples of scientists who sacrificed their lives in the pursuit of acquiring new knowledge for us all.

1. Carl Scheele (1742-1786)
Scheele was a pharmaceutical chemist and he discovered several chemical elements, including oxygen, molybdenum, tungsten, manganese and chlorine. He used toxic substances for his experiments and many of the elements he identified were also later found to be harmful. In addition, he had the habit of tasting any new substance he discovered! Long term exposure to arsenic, mercury, lead, and tasting of compounds he discovered, like hydrofluoric acid, eventually led to his death by poisoning and kidney failure by age 43.

2. Elizabeth Ascheim (1859-1905)
A young bookkeeper from San Francisco, Elizabeth Fleischman Ascheim quit her job to study electrical science upon learning of the discovery of X-rays. She soon opened the first X-ray studio in the city and began to obsessively self-experiment in the name of science. She gained a reputation as a pioneer in the field and a remarkable radiologist. However, unaware of the deadly consequences of radiation exposure, she died of an extremely widespread and violent cancer, and is remembered as one of the ‘martyrs of radiology’.

3. Alexander Bogdanov (1873-1928)
A Russian physician, philosopher, economist, and a science fiction writer, Bogdanov was a pioneer in hematology and founder of an Institution for blood transfusions. He performed eleven transfusions himself, which – he stated – cured his balding and improved his eyesight. Unfortunately, in 1928, Bogdanov took a transfusion of blood from a young man infected with malaria and tuberculosis that shortly led to his death.

4. Marie Curie (1867-1934)
Madame Curie discovered radium and polonium [named after her homeland], along with her husband Pierre. She spent rest of her life performing radiation research and studying radiation therapy. Her continued exposure to radiation led to her contracting leukemia and dying in 1934. Curie is the first and only person who received two Nobel prizes in science in two different fields, chemistry and physics.The discovery of radium took the lives of many other people working in the Curie Laboratory, including two young assistants of Madame Curie, Marguerite Perey and Sonia Cotelle.

5. Jean Francois De Rozier (1754-1785)
Jean Francois was a teacher of Chemistry and Physics. In 1783, he witnessed the world’s first balloon flight that created a passion in him for flight. After testing various flights of sheeps, chickens, and ducks, he took the first manned free flight in a balloon. He traveled at an altitude of 3,000 feet using a hot air balloon. Later, De Rozier planned a crossing of the English Channel from France to England. He took the flight but unfortunately, after reaching 1,500 feet in a combined hot air and gas balloon, the balloon deflated and he fell to his death.

6. Louis Slotin (1910-1946)
Slotin worked on the US project to design the first nuclear bomb. While performing experiments for his project, he accidentally dropped a sphere of beryllium on to a second sphere, causing a prompt critical (the spheres were wrapped around a plutonium core). Other scientists who were also in the room at the time said to have witnessed a ‘blue glow’ of air ionization and felt a heat wave. Slotin was rushed to hospital where he died nine days later. The amount of radiation he was exposed to was equivalent to standing 4800 feet away from an atomic bomb explosion.

7. Haroutune Daghlian Jr. (1921-1945)
American physicist Harry Daghlian was part of on the Manhattan Project at the remote Omega Site facility at Los Alamos National Laboratory in New Mexico. On Aug 21,1945, during a critical mass experiment, he accidentally dropped a tungsten carbide brick onto a plutonium bomb core. Oopsy. The mishap caused a critical reaction, and Daghlian quickly tried to knock the brick away, unsuccessfully, and resorted to removing the bricks by hand to halt the reaction. He stopped the reaction, but was exposed to massive amounts of radiation. He died 25 days later.

8. Malcolm Casadaban (1949-2009)
An associate professor of molecular genetics and cell biology and microbiology at the University of Chicago, specialist Casadaban was performing laboratory research on the bacterium that causes the plague when he became sick and died from plague. According to The Centers for Disease Control, the strain that killed Casadaban had never been known to infect laboratory workers, as it was a genetically weakened strain. Casadaban was found to have undiagnosed hereditary hemochromatosis, which likely played in a role in his death.

9. Richard Din (1987-2012)
Researcher Richard Din worked at the Northern California Institute for Research and Education, where the focus of his research was developing a vaccine to protect against the dangerous bacterium known as Neisseria meningitidis, a strain of bacteria that causes meningococcal disease. The UC Berkeley graduate came down with a headache and nausea, and by the next morning his symptoms had worsened enough to require a hospital visit. His condition deteriorated quickly, and he died 17 hours after his symptoms first appeared. The cause? Meningococcal disease from the bacterium he had been working on. No accidents had occurred, and Din was said to have been a fastidious, rule-following worker, but he wasn’t vaccinated for the illness despite CDC recommendations to the contrary. (Although, likely a vaccine wouldn’t help, since it was a vaccine he was working on for a strain that was resistant to vaccine.) Fortunately, about 70 people who came into contact with Din promptly received antibiotic treatment and none of them came down with the illness.

10. Jesse Lazear (1866-1900) and Clara Maass (1876-1901)
A United States convoy of doctors and nurses left for Cuba at the start of the 20th century to study yellow fever and the disease’s mode of transmission. The research involved some human and self-experimentation, where doctors and nurses would let infected mosquitos bite them and track disease incidence. Doctor Jesse William Lazear and nurse Clara Maass died of yellow fever during the course of the experiments. Many researchers and people recruited for the project let themselves be bitten by mosquitoes. Some were injected with blood from the victims of yellow fever. A few people in this test group developed the disease, but all recovered to full health. The research answered the question of how yellow fever was spread and shed light into the immunity from the disease.

11. Carlo Urbani (1956-2003)
On February 28, 2003, the Vietnam-France Hospital in Hanoi asked Carlo Urbani for help. The Italian doctor was an expert on communicable diseases. He was based in Vietnam for the World Health Organization. The hospital asked Dr. Urbani to help identify an unusual infection. He recognized it as a new threat. He made sure other hospitals increased their infection-control measures. On March 11th, Dr. Urbani developed signs of severe acute respiratory syndrome. Four days later, the World Health Organization declared it a worldwide health threat. Carlo Urbani was the first doctor to warn the world of the disease that became known as SARS. He died of the disease on March 29, 2003. He was only 46 years old.

This list is by no mean exhaustive. Many scientists, medical practitioners and researchers died pursuing their work, either through naivety, accidents, self-experimentation – being unaware of the dangerous substances they were working with, in the name of human advancements.

Many more names can be added, for instance doctors, such as Dr. Victor Willoughby, nurses, medical staff, administrators and others that died in the latest Ebola outbreak in West Africa. This blog represents a small beacon of gratitude to the many heroic scientists and researchers who devoted their lives to the medical science. They should never be forgotten.


References: 



Tuesday, February 3, 2015

Science Art Work of the Month: January 2015

This month Know-Science presents:

paraSITE by Michael Rakowitz


 

The paraSITE shelter of Michael M. on 26th Street and 9th Avenue in New York.

Urban winters are the toughest for the homeless and sometimes below zero temperatures can cause death to those sleeping in the streets.
Artist Michael Rakowitz, while still a student at MIT, started designing a smart urban shelter for the homeless which uses excess heat from building HVAC systems to inflate and warm its structure. The paraSITE shelters are collapsible, cost under $5, are made with clear and sometimes Ziploc plastic bags and can be customized to fit different spatial requirements.

For more information on Michael Rakowitz's work please visit http://michaelrakowitz.com/projects/

Wednesday, January 21, 2015

American Museum of Natural History | Shelf Life



The American Museum of Natural History invites you to dive deep inside the its collection to discover the past, present, and future of approximately 33 million artifacts and specimens in this new series with original monthly videos.




Head over to amnh.org/shelflife, where you can watch the first three episodes and learn more about the project. You can also follow the Museum on Tumblr and Twitter, where they’re constantly adding new Shelf Life content. 

EPISODE FOUR | PREMIERES FEBRUARY 17, 2015.

Monday, December 15, 2014

Science Art Work of the Month: December


Following Luke Jerram's HIV (series 2) and Rob Kesseler's Sphagnum moss, we are so pleased to have yet another wonderful and inspiring artist, Jennifer Wen Ma, accept to be a part of our kNow-Science Artwork of the Month series.

Below, Inked Garden by Jennifer Wen Ma, currently on view at the Vancouver Art Gallery.


Inked Chandelier
courtesy of Jennifer Wen Ma's studio

Inked Chandelier (2014), a large-scale installation composed of more than 700 live plants, mostly native to Canada’s West Coast, is painted completely black with Chinese ink. Suspended from the oculus of the Vancouver Art Gallery’s rotunda, the plants continue to grow as green buds sprout from the blackness. The site-specific work is a dialogue between the past and present, in which Ma pays homage to the legacy of ink painting by emphasizing time as an element of the composition: viewers observe the live installation transform over the duration of the exhibition.

For further information on the work of Jennifer Wen Man please visit littlemeat.net

Tuesday, December 9, 2014

Girl's own immune system engineered to fight leukemia

Cancer free thanks to a new Immunotherapy for Childhood Acute Lymphoblastic Leukemia: Emily's story.


9-year-old Emily Whitehead is the first girl to be cured, as of 2012, of a highly aggressive form of acute lymphoblastic leukemia (ALL) via a novel form of immunotherapy against leukemias. The girl did not respond successfully to chemotherapy before she entered as the first patient of a new trial by study leader Stephan A. Grupp, M.D., Ph.D., a pediatric oncologist at The Children's Hospital of Philadelphia and a Professor of Pediatrics at the Perelman School of Medicine of the University of Pennsylvania. What the team did was to bioengineer T cells to work not against pathogens, viruses, bacteria etc. but to recognize and kill the leukemia cells that normally evade regular T cell surveillance. 

What is a T cell?
T-cells are a type of white blood cell that circulate around our bodies, scanning for cellular abnormalities and infections.

Adding a receptor on T-cells allow them to recognize the
target cell - in this case the cancer cell - and kill it.
Our immune system often struggles to recognize cancer cells
as foreign, because the cancer cell is actually very similar to
many other cells in our body. 

Researchers first extracted the patient's own T cells and added a receptor to them that specifically recognize an antigen, an antenna that specifically marked these cancer cells. Once the T cell receptor binds to the cancer cell antigen, the T cell is able to kill the cancer cell as effectively as our immune system kills many viruses and bacteria. This is a powerful method to utilize patient's own arsenal in their immune system against cancer. 

 This past July, the U.S. Food and Drug Administration designated the so called CTL019 approach as a Breakthrough Therapy, helping to expedite its progress into broader clinical trials. While it's very early days, the future looks promising for such therapies. Source of the news can be found here.


Tuesday, December 2, 2014

Giving Tuesday 2014

Dear kNOW-SCIENCE Supporters,


Did you know that giving money to a worthwhile cause can make you happier?

Make kNow-Science your worthwhile cause this year.



https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=QDST9P2NWXQTC
As 2014 draws to a close, we can look back on a successful year of kNow-Science growth. A great series of talks at Genspace, The birth of kNow-Science Kids and an active Mythbusters Blog dispelling, or confirming, those old wives tales. To all who have attended talks and events have helped keep us going with your enthusiasm, support and smiles, we thank you and look forward to seeing you again in the future.

We rely on volunteers and also your generosity to keep growing and developing on the path we have thus far travelled.
So why not take the opportunity and show your support of kNow-Science with a donation, and help us continue to bring you the knowledge you didn't know you needed.

Tuesday, November 25, 2014

Are e-cigarettes harmless?

Are e-cigarettes harmless?




E-cigarettes, this unknown.  

Using our Ask the Expert form, Matthew Guidetti asked KNow Science about e-cigarettes. 

Are they healthy or not? 
                 Are they worse or better than normal cigarettes? 

                                                                       What are their side effects?

Astonishingly, scientists have published more than 300 scientific papers on e-cigarettes since 2009. Probably right after the first e-cigarette set foot on the market, when it was just a niche habit or an alternative to cigarettes for the elite, scientists all over the globe were already busy experimenting with e-cigarettes i.  Data ranges from their modes of action, how routes of administration change their effects and whether they are ultimately safer than conventional cigarettes.

Why has all this science not reached the public? Why are people still uncertain about e-cigarettes when we [scientists[ know so much? 

kNow-Science put two of our scientists, cancer expert Dr. Simona Giunta and brain biologist Dr. Ilaria Ceglia on the task of extracting comprehensible information from the jungle of published data.

So, what's the consensus? 

Here are three main conclusions. Some are predictable, others definitely worth knowing!

1 – E-cigarettes are a great way to stop smoking.

2 – E-cigarettes are dangerous in a different way to normal cigarettes. While tarmac and other toxic substances are gone, the metal mechanisms in many e-cigarettes produced upon vaporization have been shown to release heavy metals, which you inhale with each puff 1-2.  A much better choice is all-ceramic e-cigarettes, which do not contain metallic parts, and hence have less risk of releasing heavy metals.

3 – E-cigarettes still have all the side effects of nicotine use. Changes to heart rate and blood pressure and propensity to cause lung cancer are still there 3-4. Ingesting large quantities of nicotine, whichever the route, is not advisable from a health perspective. 

The benefit of e-cigarettes over conventional cigarettes is that they can facilitate smoking cessation 5-6.

Lung cancer is the number one killer cancer in the world for both men and women. It accounts for 13% of all new cancers, and a recent, extremely well controlled study showed convincingly that about 90% of lung cancers are due to smoking. [i]i

Doing the simple math, this means that if the all the smokers quit tomorrow the incidence of cancers overall would decrease by over 10%.
Now that you know the [scientific] truth about e-cigarettes, will you embrace the [scientific] truth about health and change your life accordingly?

Thanks for reading from the kNow-Science team.







4.     http://www.ncbi.nlm.nih.gov/pubmed/24343348

i  http://www.ecigalternative.com/ecigarette-studies-research.htm
i[i] U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the U.S. Surgeon General, 2004.